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VA RESEARCH: IBUPROFEN LINKED TO REDUCED RISK OF
ALZHEIMER'S DISEASE -- The study found veterans
who
specifically used ibuprofen for more than five
years were
more than 40% less likely to develop Alzheimer's
disease.
For more about VA research, use the VA Watchdog
search engine...click here...
http://www.yourvabenefits.org/sessearch.php?q=va+research&op=ph
Story here...
http://www.sciencedaily.com/releases/2008/05/080505162913.htm
Story below:
-------------------------
Ibuprofen Linked To Reduced Risk Of Alzheimer's
Disease
ScienceDaily — Long-term use of ibuprofen and other drugs commonly used
for aches and pains was associated with a lower risk of Alzheimer's
disease, according to a study published in the May 6, 2008, issue of
Neurology®, the medical journal of the American Academy of Neurology.
Previous studies have shown conflicting results, but this is the longest
study of its kind.
For the study, researchers identified 49,349 US veterans age 55 and older
who developed Alzheimer's disease and 196,850 veterans without dementia.
The study examined over five years of data and looked at the use of
several non-steroidal anti-inflammatory drugs (NSAIDs). The veterans
received medical care and prescriptions through the VA Health Care system.
The study found people who specifically used
ibuprofen for more than five years were more than 40 percent less likely
to develop Alzheimer's disease. Results also showed that the longer
ibuprofen was used, the lower the risk for dementia. In addition, people
who used certain types of NSAIDs for more than five years were 25 percent
less likely to develop Alzheimer's disease than non-users.
While other NSAIDs such as indomethacin may also have been associated with
lower risks, others such as celecoxib did not show any impact on dementia
risk. "These results suggest that the effect may be due to specific NSAIDs
rather than all NSAIDs as a class," said study author Steven Vlad, MD,
with Boston University School of Medicine.
 "Some
of these medications taken long term decrease the risk of Alzheimer's
disease, but it's very dependent on the exact drugs used. It doesn't
appear that all NSAIDs decrease the risk at the same rate," said Vlad.
"One reason ibuprofen may have come out so far ahead is that it is by far
the most commonly used."
Observational studies such as this one must be interpreted with the
understanding that they do not prove that an NSAID has a therapeutic
effect. The study is subject to what is called "indication bias." That
means that it might not be the NSAID use that drove the lower risk of
dementia, but rather something about the people who chose to use the
NSAIDs that was responsible. These findings should not be taken to mean
that NSAIDs should be administered to prevent dementia.
The most common side effects of NSAIDs are nausea, vomiting, diarrhea,
dizziness, constipation and headache.
The study was supported by grants from the National Institutes of Health.
Adapted from materials provided by American Academy of Neurology.
-------------------------
posted by Larry
Scott
Founder and Editor
VA Watchdog dot Org
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